منابع مشابه
Overexpression of tumor necrosis factor receptor-associated protein 1 (TRAP1), leads to mitochondrial aberrations in mouse fibroblast NIH/3T3 cells
Cancer cells undergo uncontrolled proliferation, and aberrant mitochondrial alterations. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein. TRAP1 mRNA is highly expressed in some cancer cell lines and tumor tissues. However, the effects of its overexpression on mitochondria are unclear. In this study, we assessed mitochondrial changes accompanying...
متن کاملThe TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
Many diverse activities of tumor necrosis factor (TNF) are signaled through TNF receptor 1 (TNFRl). We have identified a novel 34 kDa protein, designated TRADD, that specifically Interacts with an Intracellular domain of TNFRl known to be essential for mediating programmed cell death. Overexpression of TRADD leads to two major TNF-Induced responses, apoptosis and activation of NF-KB. The C-term...
متن کاملTumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Most cases are sporadic and its etiology is incompletely understood. However, increasing evidence suggests that oxidative stress and mitochondrial dysfunction may be involved in the pathogenesis of Parkinson's disease. The aim o...
متن کاملComment on: Failure of anti-TNF therapy in TNF receptor 1-associated periodic syndrome (TRAPS).
There was no history of ischaemic heart disease, but a routine ECG performed in April 2006 showed first-degree heart block, at a rate of 70 beats/min. Patients having infliximab in our unit are admitted overnight for the first three infusions. The first infusion was uneventful at week 0. Following the second infusion 2 weeks later, she then gave a history of dry cough for 3–4 months. A chest X-...
متن کاملBone morphogenic protein receptor type 1a (BMPR1A) and Caveolin-1 associated with trastuzumab resistance of breast cancer cells
Trastuzumab is a specific monoclonal antibody used for therapeutic of the human epidermal growth factor receptor 2 (HER-2) -positive metastatic breast cancer. But, resistance to trastuzumab is a major obstacle in clinical efficiency. During the past years, several studies have been done to find the mechanisms contributing to trastuzumab resistance. Previous studies have highlighted that bone m...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/44999